政府計畫(GRB),建議「依年度遞減排序」,以查看最新的研究方向。
畢業學年度 | 論文標題 | 連結 | 學位 | 畢業時長(years) |
---|---|---|---|---|
關鍵字 | ||||
112 | Naja ... Naja atra(臺灣眼鏡蛇)基因預測及RNA-seq識別毒腺毒素基因表現 (Gene Prediction and RNA-seq Identification of Toxin Gene Expression in the Venom Gland of Naja atra (Taiwan Cobra)) | NTHU NDLTD | 碩 | 2.00 |
台灣眼鏡蛇(Naja atra)、基因預測(Gene prediction)、毒素基因(Toxin gene) 台灣眼鏡蛇... | ||||
112 | 使用環形重... 使用環形重組技術探討雙特異性磷酸酶26活性的關鍵結構 (Using circular permutation technique to explore the key structural switch controlling the activity of dual-specificity phosphatase 26) | NTHU NDLTD | 碩 | 1.96 |
雙特異性磷酸酶26(dual-specificity phosphatase 26)、環形重組技術(circular permutation) 雙特異性磷... | ||||
112 | Naja ... Naja atra基因組資料庫的構建:從序列組裝到蛋白質預測和注釋 (Construction of a genomic database for the Naja atra: from sequence assembly to protein prediction and annotation) | NTHU NDLTD | 碩(外籍生) | 2.85 |
眼鏡蛇(Naja)、生物資訊學(Bioinformatics)、基因注釋(Annotation)、數據庫(Database)、基因組組裝(Assembly) 眼鏡蛇(N... | ||||
112 | 探究DUS... 探究DUSP-16的三環相互作用與潛在藥物靶向位點 (Exploring DPN Tri-loop Interaction and Potential Drug Targeting Sites of DUSP16) | NTHU NDLTD | 碩 | 2.84 |
雙特異性蛋白磷酸酶16(DUSP16)、三環相互作用(DUSP16 dual specificity phosphatase 16)、潛在藥物靶向位點(DPN Tri-loop Interaction) 雙特異性蛋... | ||||
112 | 系統性紅斑... 系統性紅斑狼瘡患者的雙特異性磷酸酶22變異體之構效關係研究 (The study on the structure-activity relationship of dual-specificity phosphatase 22 (DUSP22) gene variants from systemic lupus erythematosus (SLE) patients) | NTHU NDLTD | 碩 | 2.59 |
系統性紅斑狼瘡(systemic lupus erythemaatosus)、雙特異性磷酸酶22(dual-specificity phosphatase 22)、雙特異性磷酸酶(dual-specificity phosphatase)、T細胞受體(T-cell receptor)、淋巴細胞特異性蛋白酪胺酸激酶(Lck) 系統性紅斑... | ||||
111 | 經由結構特... 經由結構特性探討抗體鎖的遮蔽能力 (Revealing the Blocking Ability of Antibody Locks through Structural Characterization) | NTHU NDLTD | 碩 | 1.96 |
單株抗體(mAb)、程式性死亡-1(PD-1)、納武單抗(Nivolumab)、抗體鎖(Ab-lock) 單株抗體(... | ||||
111 | 環狀序列重... 環狀序列重組蛋白質搜尋演算法SeqCP之開發及應用 (Development and application of SeqCP, a sequence-based algorithm for circularly-permuted protein identification) | NTHU NDLTD | 博 | 9.47 |
環狀序列重組(Circular permutation)、環狀序列重組蛋白質(Circular permutants)、蛋白質序列分析(Protein sequence analysis)、蛋白質結構模型(Protein structure modeling) 環狀序列重... | ||||
111 | 對雙特異性... 對雙特異性磷酸酶26構效關係之研究 (Study on the structure – activity relationship of dual-specificity phosphatase 26) | NTHU NDLTD | 碩 | 2.38 |
磷酸酶(phosphatase)、雙特異性磷酸酶(dual-specificity phosphatase)、雙特異性磷酸酶 26(dual-specificity phosphatase 26)、構效關係(structure-activity relationship)、結構模擬(structural modeling) 磷酸酶(p... | ||||
110 | 人類雙重特... 人類雙重特異性去磷酸酵素10中 DPN-三環互相作用的結構與功能研究 (Study on the structure and function of DPN-triloop interaction in human dual-specificity phosphatase 10) | NTHU NDLTD | 碩 | 1.97 |
人類雙重特異性去磷酸酵素10(human dual-specificity phosphatase 10)、DPN-三環互相作用(DPN-triloop interaction) 人類雙重特... | ||||
110 | 結構解析與... 結構解析與活性分析胺基醣苷類抗生素-春日黴素之生合成及抗性表現相關酵素 (Structural and Biochemical Analysis of Enzymes Involved in the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and Its Resistance) | NTHU NDLTD | 博 | 7.67 |
春日黴素(kasugamycin)、春日胺基(kasugamine)、抗生素之生物合成(antibiotic biosynthesis)、表異構酶與乙酰轉移酶(epimerase) 春日黴素(... | ||||
109 | 利用貝氏推... 利用貝氏推論分析SPOUT扭結蛋白家族的結構演化及其先祖蛋白序列的重構 (The structural phylogenetic analysis of SPOUT trefoil-knotted protein family by Bayesian inference and the reconstruction of ancestral sequences) | NTHU NDLTD | 碩 | 4.13 |
扭結蛋白(knotted protein)、譜系分析(phylogenetic analysis)、先祖序列重建(ancestral sequence reconstruction) 扭結蛋白(... | ||||
109 | 鹽橋在芳烷... 鹽橋在芳烷基胺乙醯基轉移酶之結構與功能探討 (Structural and functional insights into the role of the salt bridge in arylalkylamine N-acetyltransferase) | NTHU NDLTD | 碩 | 1.97 |
乙醯基轉移酶(N-acetyltransferase)、乙醯輔酶A(acetyl-coenzymeA)、X射線晶體學(X-ray crystallography)、芳烷基胺乙醯轉移酶(arylalkylamine N-acetyltransferase)、胍丁胺(agmatine)、等溫滴定量熱法(ITC) 乙醯基轉移... | ||||
109 | 天然核甘抗... 天然核甘抗生素-卡普拉霉素生合成途徑關鍵酵素之解析與研究 (Identification and Evaluation of Key Enzymes in Biosynthesis of Nucleoside Antibiotic Caprazamycin) | NTHU NDLTD | 博 | 6.94 |
卡普拉霉素(Caprazamycin)、磷酸-N-乙酰胞壁酰-五肽轉位酶(phospho-N-acetylmuramyl-pentapeptide translocase (MraY))、β-羥化酶(β-hydroxylase) 卡普拉霉素... | ||||
109 | 探討帶有N... 探討帶有N環的蛋白質酪胺酸磷酸酶: 雙特異性磷酸酶22中形成活性位點的結構見解 (The Study of N-loop-containing Protein Tyrosine Phosphatase: Structural Insights into the Active Site Formation of DUSP22) | NTHU NDLTD | 博 | 8.47 |
蛋白質酪胺酸磷酸酶(Protein tyrosine phosphatases)、雙特異性磷酸酶(DUSPs)、活性位(Active site)、氫鍵網路(Hydrogen bonding network)、N環(N-loop)、雙特異性磷酸酶22(DUSP22) 蛋白質酪胺... | ||||
109 | 乙醯輔酶A... 乙醯輔酶A在昆蟲芳烷基胺N-乙醯基轉移酶催化循環中蛋白構象調節的重要作用 (An essential role of acetyl coenzyme A in the regulation of protein conformation of insect arylalkylamine N-acetyltransferase (AANAT) in the catalytic cycle) | NTHU NDLTD | 博 | 7.40 |
芳烷基胺N-乙醯基轉移酶(arylalkylamine N-acetyltransferase)、乙醯輔酶A(acetyl coenzyme A)、多巴胺N-乙醯基轉移酶(dopamine N-acetyltransferase) 芳烷基胺N... | ||||
108 | 無扭結環形... 無扭結環形重組蛋白YbeA形成區域交換之摺疊路徑探討 (Insights into the folding pathway of an unknotted and domain-swapped circular permutant of YbeA) | NTHU NDLTD | 碩 | 1.86 |
扭結蛋白(YbeA)、區域交換(knotted)、環形重組(domain-swapping)、摺疊路徑(folding) 扭結蛋白(... | ||||
108 | 胍丁胺乙醯... 胍丁胺乙醯基轉移酶突變蛋白的單元體及二元體/三元體晶體結構研究以探討酵素活性之關鍵殘基 (Studies of crystal structures of apo form and binary/ternary complexes of agmatine N-acetyltransferase mutant reveal the key residues for enzyme activity.) | NTHU NDLTD | 碩 | 1.86 |
乙醯基轉移酶(N-acetyltransferase)、乙醯輔酶A(acetyl-coenzymeA)、X射線晶體學(X-ray crystallography)、共結晶(co-crystallization)、苯烷基胺乙醯轉移酶(arylalkylamine N-acetyltransferase)、胍丁胺(agmatine)、等溫滴定量熱法(ITC)、艾爾曼試劑(DTNB) 乙醯基轉移... | ||||
108 | Acb C... Acb Complex 碳青黴烯抗藥性臨床分離株之基因序列分析 (Genome Sequence Analysis for Carbapenem-Resistant Clinical Isolates of Acb Complex) | NTHU NDLTD | 碩 | 1.84 |
次世代定序(Next Generation Sequencing)、多位點序列分型(Multilocus Sequence Typing)、抗藥性(Drug Resistance)、葡萄糖去氫化酶(Glucose Dehydrogenase B)、感染(Infection) 次世代定序... | ||||
108 | 建立完整的... 建立完整的人類癌症突變特徵資料庫 (Establishment of a comprehensive database for characterizing mutational signatures in human cancers) | NTHU NDLTD | 碩(提早入學) | 1.93 |
突變特徵(mutational signatures) 突變特徵(... | ||||
108 | 果蠅乙醯基... 果蠅乙醯基轉移酶類似蛋白第二型之結構暨功能分析 - 揭示其酶活性所需的關鍵殘基 (Structure-function analysis of Drosophila melanogaster Arylalkylamine N-Acetyltransferases Like 2 protein - uncovering the key residues required for enzyme activity) | NTHU NDLTD | 碩 | 2.33 |
乙醯基轉移酶(Arylalkylamine N-acetyltransferase like)、乙醯化作用(Arylalkylamine N-acetyltransferase)、乙醯輔酶A(Acetylation)、等溫滴定微量熱儀(Acetyl-coenzyme A)、結合親和力(binding order in radom fashion)、熱力學(Isothermal titration calorimetry)、艾爾曼的試劑(Thermodynamics)、定位突變(Binding affinity)、酵素動力學(Ellman's reagent)、蛋白質結構(Site-directed mutagenesis) 乙醯基轉移... | ||||
108 | 果蠅乙醯基... 果蠅乙醯基轉移酶類似蛋白第七型之結構暨功能分析 - 揭示其酶活性所需的關鍵殘基 (Structure-function analyses of Drosophila melanogaster Arylalkylamine N-Acetyltransferases Like 7 protein - uncovering the key residues required for enzyme activity) | NTHU NDLTD | 碩 | 2.21 |
果蠅乙醯基轉移酶類似蛋白第七型(arylalkyamine N-acetyltransferase like 7)、乙醯輔酶A(acetyl-CoA)、苯乙胺(phenethylamine) 果蠅乙醯基... | ||||
107 | 果蠅乙醯基... 果蠅乙醯基轉移酶類似蛋白第八型之結構暨功能分析 - 揭示其酶活性所需的關鍵殘基 (Structure-function analyses of Drosophila melanogaster Arylalkylamine N-Acetyltransferases Like 8 protein - uncovering the key residues required for enzyme activity) | NTHU NDLTD | 碩 | 2.00 |
乙醯基轉移酶(N-acetyltransferase)、乙醯化作用(N-acetylation)、乙醯輔酶A(acetyl-coenzymeA)、芳烴基烷基胺(arylalkylamine)、等溫滴定量熱法(ITC)、艾爾曼的試劑(DTNB) 乙醯基轉移... | ||||
107 | 癌症基因體... 癌症基因體變異視覺化整合分析工具 (A web tool for visual summary of mutations in cancer cohorts) | NTHU NDLTD | 碩 | 1.97 |
癌症基因體(CoMut plot)、全外顯子基因定序(WES)、基因註解(Annotation)、突變特徵(Mutational Signature) 癌症基因體... | ||||
107 | 降解RNA... 降解RNA之核酸外切酶的結構與功能研究 (Structural insights into 3′-to-5′ exoribonucleases in RNA turnover) | NTHU NDLTD | 博 | 4.85 |
RNA降解(RNA turnover)、核酸外切酶(exoribonuclease)、蛋白質結構(crystal structure) RNA降解... | ||||
106 | 核糖核酸水... 核糖核酸水解酶PNPase突變導致疾病之結構解析 (Structural insights into the disease-linked human PNPase mutants in RNA binding and degradation) | NTHU NDLTD | 博 | 5.00 |
RNA 降解(RNA decay)、粒線體RNA 導入(mitochondrial RNA import)、粒線體蛋白(mitochondrial proteins)、核醣核酸酶(exoribonuclease)、蛋白質結構(crystal structure) RNA 降... | ||||
106 | 環形重組技... 環形重組技術於扭結蛋白YbeA上的結構與折疊過程影響 (Effects of circular permutation on the structure and folding pathway of trefoil-knotted protein YbeA) | NTHU NDLTD | 碩 | 1.85 |
環形重組(circular permutation)、扭結蛋白(knotted protein)、區域交換(domain swap)、蛋白摺疊(YbeA) 環形重組(... | ||||
106 | 以環形序列... 以環形序列重組解開三葉型扭結蛋白YibK之拓樸結的影響 (Impacts of untying a topological knot in trefoil-knotted protein YibK by circular permutation) | NTHU NDLTD | 碩 | 1.85 |
扭結蛋白(knotted protein)、環形序列重組(circular permutation)、蛋白質拓樸結構(protein topology)、蛋白質摺疊(protein folding) 扭結蛋白(... | ||||
105 | 建構人類雙... 建構人類雙重特異性去磷酸酵素22之C-端截斷突變及其結構與功能探討 (Construction of C-terminal Truncated Human Dual-Specificity Phosphatase 22 for Structural and Functional Studies) | NTHU NDLTD | 碩 | 2.99 |
雙重特異性去磷酸酵素22(DUSP22) 雙重特異性... | ||||
105 | 建構熱啟動... 建構熱啟動 Taq 去氧核醣核酸聚合酵素及其突變蛋白之功能研究 (Construction of a hot start Taq DNA polymerase and functional studies of its mutants) | NTHU NDLTD | 碩 | 1.99 |
熱啟動(Hot start)、去氧核醣核酸聚合酶(Taq DNA polymerase)、突變(mutants)、建構蛋白(Construction) 熱啟動(H... | ||||
105 | 雙功能CS... 雙功能CSαβ模組之分子設計 (Molecular Design of a Dual Functional Cysteine-Stabilized αβ (CSαβ) Motif) | NTHU NDLTD | 碩 | 0.99 |
CSαβ模組(CSαβmotif)、植物防禦素(plantdefensin)、蠍毒蛋白(scorpiontoxin) CSαβ模... | ||||
104 | 連接長度及... 連接長度及雙硫鍵對綠豆防禦素環形重組突變之影響 (The Effects of Linker Length and Disulfide-bond Constraint on Circularly Permuted Vigna radiata Plant Defensin 1) | NTHU NDLTD | 碩 | 暫無口試日期 |
環形重組(Circular permutation)、綠豆植物防禦素第一型(Vigna radiata plant defensin 1)、連接胜肽長度(linker length)、雙硫鍵(disulfide bond) 環形重組(... | ||||
104 | 果蠅脂肪酸... 果蠅脂肪酸結合蛋白的純度鑑定與微脂體交互作用探討 (Purity and Liposome Interaction of Drosophila Fatty Acid Binding Proteins) | NTHU NDLTD | 碩 | 暫無口試日期 |
果蠅脂肪酸結合蛋白(Drosophila Fatty Acid Binding Proteins)、純度鑑定(Purity)、微脂體(Liposome)、氣相層析(Gas chromatography)、核磁共振(nuclear magnetic resonance spectroscopy) 果蠅脂肪酸... | ||||
104 | 果蠅多巴胺... 果蠅多巴胺乙醯轉移酶催化循環與結構關聯性之研究 (The Relationship between the Catalytic Cycle and Structure of Dopamine N-Acetyltransferase from Drosophila melanogaster) | NTHU NDLTD | 碩 | 暫無口試日期 |
多巴胺乙醯轉移酶(Dopamine N-acetyltransferase)、苯烷基胺乙醯轉移酶(arylalkylamine N-acetyltransferase)、定序二二連續型機制(Ordered bi bi sequential mechanism)、等溫滴定量熱儀(Isothermal titration calorimetry)、X射線晶體學(X-ray crystallography)、共結晶(Co-crystallization)、催化循環(Catalytic cycle) 多巴胺乙醯... | ||||
104 | 研究果蠅多... 研究果蠅多巴胺乙醯基轉移酶的次序連續性機制及結合位點上的關鍵殘基 (Study of the ordered sequential mechanism and critical residues in binding site of Drosophila melanogaster dopamine N-acetyltransferase) | NTHU NDLTD | 碩 | 暫無口試日期 |
多巴胺乙醯基轉移酶(Dopamine N-acetyltransferase)、芳烴基烷基胺乙醯基轉移酶(Arylalkylamine N-acetyltransferase)、乙醯化作用(Acetylation)、乙醯輔酶A(Acetyl-coenzyme A)、次序連續性機制(Ordered sequential mechanism)、酵素再循環(Enzyme recycling)、等溫滴定微量熱儀(Isothermal titration calorimetry)、核磁共振儀(Nuclear magnetic resonance)、熱力學(Thermodynamics)、結合親和力(Binding affinity)、化學位移(Chemical shift)、艾爾曼的試劑(Ellman's reagent)、構型變化(Conformational change)、結合位(Binding site)、定位突變(Site-directed mutagenesis)、酵素動力學(Enzyme kinetics)、輔助因子結合殘基(Cofactor binding residue)、蛋白質結構(Protein structure) 多巴胺乙醯... | ||||
104 | 複合體SW... 複合體SWI5-SFR1c與RAD51作用中SWI5 C端所扮演的角色 (Role of the SWI5 C-terminal loop in SWI5-SFR1c complex interaction with RAD51) | NTHU NDLTD | 碩 | 暫無口試日期 |
swi5-sfr1蛋白質複合體(swi5-sfr1 protein complex)、rad51重組酶(rad51 recombinase)、DNA同源重組修復(DNA homologous recombination repair) swi5-... | ||||
103 | 果蠅多巴胺... 果蠅多巴胺乙醯基轉移酶的基質通道大小對酵素活性之影響 (The size effect of substrate-entrance tunnel of Dopamine N-acetyltransferase on its enzyme activity) | NTHU NDLTD | 碩 | 暫無口試日期 |
果蠅蛋白(Drosophila Protein)、苯烷基胺乙醯基轉移酶(Arylalkylamine N-acetyltransferase)、多巴胺乙醯基轉移酶(Dopamine N-acetyltransferase)、乙醯輔酶A(Acetyl Coenzyme A)、受質專一性(Substrate Specificity)、酵素動力學(Enzyme Kinetics)、通道瓶頸(Tunnel bottleneck) 果蠅蛋白(... | ||||
103 | 環狀序列重... 環狀序列重組應用在具有CSαβ模組的綠豆防禦素第一型之研究 (Circular permutation on cysteine- stabilized αβ motif of Vigna radiata plant defensin 1) | NTHU NDLTD | 碩 | 暫無口試日期 |
環狀序列重組(VrD1)、綠豆植物防禦素第一型(Circular permutation) 環狀序列重... | ||||
102 | 探討螺旋區... 探討螺旋區域上鹼性殘基對果蠅脂肪酸結合蛋白熱穩定性及脂肪酸結合之影響 (Basic residues in helical region affect protein stability and ligand binding in Drosophila Fatty Acid Binding Protein) | NTHU NDLTD | 碩 | 暫無口試日期 |
果蠅蛋白(Drosophila Proteins)、點突變(Mutagenesis, Site-Directed)、熱穩定性(Thermostability)、蛋白二級結構(Protein Secondary Structure)、序列比對(Sequence Alignment)、螺旋區域(Helical region)、正電荷排斥(Positive charge repulsion)、配體入口(Ligand entrance) 果蠅蛋白(... | ||||
102 | 熱誘導果蠅... 熱誘導果蠅三磷酸鳥苷水解蛋白形成類澱粉蛋白特性之研究 (Thermal induced β-amyloid-like fibrils formation in Drosophila melanogaster GTPase protein, Beck) | NTHU NDLTD | 碩 | 暫無口試日期 |
三磷酸鳥苷水解蛋白、類澱粉蛋白 三磷酸鳥苷... | ||||
102 | 研究果蠅多... 研究果蠅多巴胺乙醯基轉移酶受質的入口通道 (Study of stustrate-entrance tunnel of Dopamine N-acetyltransferase from Drosophila melanogaster) | NTHU NDLTD | 碩 | 暫無口試日期 |
乙烯基輔酶A(Acetyl Coenzyme A)、乙烯基轉移酶(Acetyltransferases)、果蠅蛋白(Drosophila Proteins)、酵素動力學(Enzyme Kinetics)、多巴胺 N-乙烯基轉移酶(Dopamine N-acetyltransferase)、受質特異性(Substrate Specificity)、受質通道(Substrate tunnel)、通道瓶頸(Tunnel bottleneck) 乙烯基輔酶... | ||||
101 | 果蠅多巴胺... 果蠅多巴胺乙醯基轉移酶之三元複合體結構與受質專一性研究 (Structural Basis for the Activity and Substrate Specificity of Dopamine N-acetyltransferase) | NTHU NDLTD | 碩 | 暫無口試日期 |
果蠅(Drosophila)、晶體(crystal) 果蠅(Dr... | ||||
101 | 酸性與鹼性... 酸性與鹼性植物非專一性脂質傳送蛋白功能與結構之比較 (Functional and Structural Comparisons of Acidic and Basic Plant Non-Specific Lipid Transfer Protein) | NTHU NDLTD | 碩 | 暫無口試日期 |
Palnt nonspecific lipid transfer protein(植物非專一性脂質傳送蛋白) Palnt... | ||||
101 | 果蠅脂肪酸... 果蠅脂肪酸結合蛋白的結構與功能分析 (Structural and Functional Analysis of Drosophila Fatty Acid-Binding Protein) | NTHU NDLTD | 碩 | 暫無口試日期 |
果蠅脂肪酸結合蛋白(dFABP) 果蠅脂肪酸... |