組蛋白去甲... 基酶PHF8於胃癌中作為代謝調節角色之研究 (Investigation of histone demethylase PHF8 as a metabolic regulator in gastric cancer)more

組蛋白去甲基酶PHF8於胃癌中作為代謝調節角色之研究 (Investigation of histone demethylase PHF8 as a metabolic regulator in gastric cancer)

WDR4促... 進PTPN23泛素化以抑制EGFR及c-MET 降解而成為肺癌治療靶點 (PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target)more

WDR4促進PTPN23泛素化以抑制EGFR及c-MET 降解而成為肺癌治療靶點 (PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target)

探討幽門螺... 旋桿菌感染期間 PldA 調節免疫反應的分子機制 (Unraveling the Molecular Mechanism of PldA in Modulating Immune Response during Helicobacter pylori Infection)more

探討幽門螺旋桿菌感染期間 PldA 調節免疫反應的分子機制 (Unraveling the Molecular Mechanism of PldA in Modulating Immune Response during Helicobacter pylori Infection)

O-Glc... NAcylation 抑制乳腺癌鐵死亡 (O-GlcNAcylation inhibits ferroptosis in breast cancer)more

O-GlcNAcylation 抑制乳腺癌鐵死亡 (O-GlcNAcylation inhibits ferroptosis in breast cancer)

PKM2 ... 透過異位調控機制調節癌細胞能量感測及癌症發展 (PKM2 regulates energy sensing and cancer progression through its allosteric regulation)more

PKM2 透過異位調控機制調節癌細胞能量感測及癌症發展 (PKM2 regulates energy sensing and cancer progression through its allosteric regulation)

膽固醇醣化... 轉移酵素的抑制劑之開發以及結構功能分析 (Discovery and structure-activity relationship of cholesterol-a-glucosyltransferase inhibitors)more

膽固醇醣化轉移酵素的抑制劑之開發以及結構功能分析 (Discovery and structure-activity relationship of cholesterol-a-glucosyltransferase inhibitors)

研究胃幽門... 螺旋菌膽固醇醣化酵素引發巨噬細胞發炎反應之機轉 (To investigate the molecular mechanisms of cholesterol-α-glucosyltransferase in inducing pro-inflammatory cytokine production in Helicobacter pylori-infected macrophages)more

研究胃幽門螺旋菌膽固醇醣化酵素引發巨噬細胞發炎反應之機轉 (To investigate the molecular mechanisms of cholesterol-α-glucosyltransferase in inducing pro-inflammatory cytokine production in Helicobacter pylori-infected macrophages)

胃幽門螺旋... 菌臨床菌株膽固醇醣基轉移酶的生化特性研究 (Biochemical characterization of cholesterol-α-glucosyltransferase from Helicobacter pylori isolates)more

胃幽門螺旋菌臨床菌株膽固醇醣基轉移酶的生化特性研究 (Biochemical characterization of cholesterol-α-glucosyltransferase from Helicobacter pylori isolates)

抑制KDM... 4以治療口腔鱗狀細胞癌的進展 (Pharmacological inhibition of KDM4 in the treatment of oral squamous cell carcinoma progression)more

抑制KDM4以治療口腔鱗狀細胞癌的進展 (Pharmacological inhibition of KDM4 in the treatment of oral squamous cell carcinoma progression)

胃癌治療標... 靶：由PHF8調控之PKCα-Src-PTEN訊號軸 (Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in gastric cancer)more

胃癌治療標靶：由PHF8調控之PKCα-Src-PTEN訊號軸 (Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in gastric cancer)

單核細胞和... 乳腺癌細胞之間的串息藉由細胞激素CXCL7分子促進乳腺癌進展 (Crosstalk Between Monocytes and Breast Cancer Cells to Promote Breast Cancer Progression via CXCL7 Mediated Signaling Pathways)more

單核細胞和乳腺癌細胞之間的串息藉由細胞激素CXCL7分子促進乳腺癌進展 (Crosstalk Between Monocytes and Breast Cancer Cells to Promote Breast Cancer Progression via CXCL7 Mediated Signaling Pathways)

組蛋白去甲... 基化酶於口腔鱗狀細胞癌進程調控機制之研究 (Study the role of histone lysine demethylases in oral squamous cell carcinoma progression)more

組蛋白去甲基化酶於口腔鱗狀細胞癌進程調控機制之研究 (Study the role of histone lysine demethylases in oral squamous cell carcinoma progression)

天然化合物... G調節丙酮酸激酶M2異構體的生化和動力學特徵 (Biochemical and Kinetic Characterization of M2-pyruvate kinase Regulation by Natural Compound G)more

天然化合物G調節丙酮酸激酶M2異構體的生化和動力學特徵 (Biochemical and Kinetic Characterization of M2-pyruvate kinase Regulation by Natural Compound G)

代謝標記與... M2極化癌症相關巨噬細胞浸潤於管腔型乳癌之關係 (Correlation of metabolic markers with M2-polarized tumor-associated macrophage infiltration in luminal breast cancer)more

代謝標記與M2極化癌症相關巨噬細胞浸潤於管腔型乳癌之關係 (Correlation of metabolic markers with M2-polarized tumor-associated macrophage infiltration in luminal breast cancer)

探討 KD... M4C 和 YAP1 在缺氧口腔鱗狀上皮細胞癌化進程所扮演的角色 (To investigate the role of KDM4C and YAP1 in oral squamous cell carcinoma progression under hypoxia)more

探討 KDM4C 和 YAP1 在缺氧口腔鱗狀上皮細胞癌化進程所扮演的角色 (To investigate the role of KDM4C and YAP1 in oral squamous cell carcinoma progression under hypoxia)

探討醣化對... PKM2結構的影響以及開發醣化PKM2單株抗體 (Biochemical characterization of O-GlcNAcylated PKM2 and development of a specific antibody against O-GlcNAcylated PKM2)more

探討醣化對PKM2結構的影響以及開發醣化PKM2單株抗體 (Biochemical characterization of O-GlcNAcylated PKM2 and development of a specific antibody against O-GlcNAcylated PKM2)

KDM4B... 與c-Jun共同調控胃癌演進 (KDM4B cooperates with c-Jun to promote gastric carcinogenesis)more

KDM4B與c-Jun共同調控胃癌演進 (KDM4B cooperates with c-Jun to promote gastric carcinogenesis)

尋找人類組... 蛋白去甲基酶KDM4抑制劑並加以修飾進而應用在治療去勢抗性前列腺癌 (Discovery and Modification of KDM4 Inhibitors in Castration-Resistant Prostate Cancer Treatment)more

尋找人類組蛋白去甲基酶KDM4抑制劑並加以修飾進而應用在治療去勢抗性前列腺癌 (Discovery and Modification of KDM4 Inhibitors in Castration-Resistant Prostate Cancer Treatment)

人類組蛋白... 去甲基酵素KDM4B在抗去勢前列腺癌之代謝適應上扮演關鍵的角色 (Histone demethylase KDM4B is crucial for metabolic adaptation of castration-resistant prostate cancer)more

人類組蛋白去甲基酵素KDM4B在抗去勢前列腺癌之代謝適應上扮演關鍵的角色 (Histone demethylase KDM4B is crucial for metabolic adaptation of castration-resistant prostate cancer)

台灣人胃癌... Kras突變發現及其功能 (Identification and characterization of somatic Kras mutations in Taiwan)more

台灣人胃癌Kras突變發現及其功能 (Identification and characterization of somatic Kras mutations in Taiwan)

好發性突變... RhoA在瀰漫型胃癌中的分子機制 (Mechanistic basis of recurrent RhoA mutation in diffuse-type gastric cancer)more

好發性突變RhoA在瀰漫型胃癌中的分子機制 (Mechanistic basis of recurrent RhoA mutation in diffuse-type gastric cancer)

以結構基礎... 來探討突變體之丙酮酸激活酵素異構調節 (The structural basis for the allosteric regulation of PKM2 variants)more

以結構基礎來探討突變體之丙酮酸激活酵素異構調節 (The structural basis for the allosteric regulation of PKM2 variants)

以片段基礎... 前導物搜索的方式去尋找人類去甲基酵素KDM4的抑制劑進而對抗前列腺癌細胞 (Fragment-Based Lead Discovery Approach to Discover Novel Inhibitors of Lysine (K)- Specific Demethylase 4 against Prostate Cancer Cells)more

以片段基礎前導物搜索的方式去尋找人類去甲基酵素KDM4的抑制劑進而對抗前列腺癌細胞 (Fragment-Based Lead Discovery Approach to Discover Novel Inhibitors of Lysine (K)- Specific Demethylase 4 against Prostate Cancer Cells)

探討人類組... 蛋白去甲基酵素KDM4B在具有雄激素受體的抗去勢前列腺癌之代謝適應上的角色 (The role of KDM4B in metabolic adaptation in AR-positive CRPC cells)more

探討人類組蛋白去甲基酵素KDM4B在具有雄激素受體的抗去勢前列腺癌之代謝適應上的角色 (The role of KDM4B in metabolic adaptation in AR-positive CRPC cells)

人類組蛋白... 去甲基酵素KDM4B之天然抑制劑開發 (Structure-based discovery of KDM4B inhibitors from natural compounds)more

人類組蛋白去甲基酵素KDM4B之天然抑制劑開發 (Structure-based discovery of KDM4B inhibitors from natural compounds)

以酵素工程... 法開發黏質沙雷氏菌BCRC10948之新型具有高催化效率短鏈脫氫酶還原酶 (Engineer a novel short-chain dehydrogenase/reductase that exhibits enhanced catalytic efficiency and exquisite substrate specificity from Serratia marcescens BCRC 10948)more

以酵素工程法開發黏質沙雷氏菌BCRC10948之新型具有高催化效率短鏈脫氫酶還原酶 (Engineer a novel short-chain dehydrogenase/reductase that exhibits enhanced catalytic efficiency and exquisite substrate specificity from Serratia marcescens BCRC 10948)

Struc... ture-guided identification of 7a-based analogues against shikimate dehydrogenase from Helicobacter pylori and Mycobacterium tuberculosis. (以7a衍生物針對幽門螺旋菌及結核分枝桿菌之莽草酸去氫酶蛋白質結構為標準之抑制劑研究)more

Structure-guided identification of 7a-based analogues against shikimate dehydrogenase from Helicobacter pylori and Mycobacterium tuberculosis. (以7a衍生物針對幽門螺旋菌及結核分枝桿菌之莽草酸去氫酶蛋白質結構為標準之抑制劑研究)

組蛋白去甲... 基酵素KDM4B調控胃幽門螺旋菌誘導之白細胞介素-8表現之研究 (KDM48, Histone Lysine-specific Demethylase, Regulates Helicobacter pylori-induced Interleukin-8 Expresson)more

組蛋白去甲基酵素KDM4B調控胃幽門螺旋菌誘導之白細胞介素-8表現之研究 (KDM48, Histone Lysine-specific Demethylase, Regulates Helicobacter pylori-induced Interleukin-8 Expresson)

突變之丙酮... 酸激活酶在代謝物調控下晶體結構與活性關係之研究 (Allosteric regulation of PKM2: Structure-activity relationship of PKM2 variants regulated by metabolites)more

突變之丙酮酸激活酶在代謝物調控下晶體結構與活性關係之研究 (Allosteric regulation of PKM2: Structure-activity relationship of PKM2 variants regulated by metabolites)

組蛋白去甲... 基酵素KDM8於常氧及缺氧環境下對乳癌細胞增生調控機制之研究 (KDM8, an H3K36me2 Histone Demethylase, Regulates Normoxia and Hypoxia Mediated Breast Cancer Cell Proliferation)more

組蛋白去甲基酵素KDM8於常氧及缺氧環境下對乳癌細胞增生調控機制之研究 (KDM8, an H3K36me2 Histone Demethylase, Regulates Normoxia and Hypoxia Mediated Breast Cancer Cell Proliferation)

人類組蛋白... 去甲基酵素KDM4B之晶體結構與抑制劑動力學研究 (Crystal Structure and Inhibitor Kinetics of Human Histone Demethylase Lysine-specific Demethylase 4B (KDM4B))more

人類組蛋白去甲基酵素KDM4B之晶體結構與抑制劑動力學研究 (Crystal Structure and Inhibitor Kinetics of Human Histone Demethylase Lysine-specific Demethylase 4B (KDM4B))

巴比妥酸衍... 生物之設計與合成應用於抗胃幽門螺旋菌藥物與莽草酸去氫酶抑制劑之開發 (Design, synthesis and biological evaluation of barbiturate-conjugated derivatives as anti-Helicobacter pylori toward the shikimate pathway)more

巴比妥酸衍生物之設計與合成應用於抗胃幽門螺旋菌藥物與莽草酸去氫酶抑制劑之開發 (Design, synthesis and biological evaluation of barbiturate-conjugated derivatives as anti-Helicobacter pylori toward the shikimate pathway)