政府計畫（GRB），建議「依年度遞減排序」，以查看最新的研究方向。
| 畢業學年度 | 論文標題 | 連結 | 學位 | 畢業時長(years) |
|---|---|---|---|---|
| 關鍵字 | ||||
| 112 | 在斑馬魚模... 在斑馬魚模型中探索可用於早期辨識化療藥物阿黴素誘導之延遲性心毒性的生物標記因子 (Exploring Early Biomarkers to Predict Doxorubicin-Induced Delay Cardiotoxicity in Zebrafish Model) | NTHU | 碩 | 無口試日期 |
斑馬魚(Zebrafish)、延遲起效(Delay-onset)、阿黴素(Doxorubicin)、心臟毒性(Cardiotoxicity)、兒科(Pediatric)、模擬模型(Simulation model)、生物標記因子(Biomarker) 斑馬魚(Z... | ||||
| 112 | 探討 LT... 探討 LTCC/NFAT 訊號傳導對斑馬魚心臟損傷反應的作用 (Exploring the Role of LTCC/NFAT Signaling on Cardiac Injury Responses in Zebrafish) | NTHU NDLTD | 碩 | 2.49 |
L型鈣離子通道(LTCC)、NFAT信號路徑(NFAT)、細胞外基質重塑(ECM remodeling)、電訊號重塑(electrical conduction remodeling)、斑馬魚心臟再生(zebrafish heart regeneration) L型鈣離子... | ||||
| 111 | 探索子宮頸... 探索子宮頸大細胞神經內分泌瘤的個人化治療策略 (Exploring Personalized Treatment Strategies for Large Cell Neuroendocrine Cervical Carcinoma) | NTHU NDLTD | 碩 | 1.99 |
子宮頸大細胞神經內分泌瘤(Large cell neuroendocrine cervical carcinoma)、精準醫療(precision medicine)、次世代定序(next-generation sequencing)、INSM1(INSM1)、DLL3(DLL3)、NOTCH1(NOTCH1)、VPA(VPA) 子宮頸大細... | ||||
| 111 | 探討同源重... 探討同源重組路徑抑制劑增強硼中子捕獲治療對多形性膠質母細胞瘤化療抗藥性細胞的療效 (Homologous recombination pathway inhibitor enhances the therapeutic effect of BNCT in chemotherapy-resistant Glioblastoma multiforme cells) | NTHU NDLTD | 碩 | 1.98 |
硼中子捕獲治療(BNCT)、多形性膠質母細胞瘤(GBM)、化療抗藥性(Chemo-resistance)、DNA 損傷修復(DNA damage & repair)、HR 路徑抑制劑(HR pathway inhibitors)、放射增敏劑(Radiosensitizers) 硼中子捕獲... | ||||
| 111 | 探討自噬作... 探討自噬作用作為預測阿黴素誘導之心臟毒性的可行性 (Exploring the potential of autophagy as a predictor for doxorubicin-induced cardiotoxicity) | NTHU NDLTD | 碩 | 2.98 |
阿黴素(Doxorubicin)、斑馬魚(Biomarker)、自噬(RNA-seq)、心毒性(Autophagy)、生物標誌物(Cardiotoxicity) 阿黴素(D... | ||||
| 110 | 以硼中子捕... 以硼中子捕獲治療清除具輻射抗性肝癌細胞並探討其DNA損傷與修復反應 (Boron neutron capture therapy eliminates radioresistant liver cancer cells by targeting DNA damage and repair responses) | NTHU NDLTD | 碩 | 1.95 |
硼中子捕獲治療(BNCT)、肝癌(HCC)、放射抗性(radioresistance)、DNA損傷(DNA damage)、DNA修復反應(DNA repair responses) 硼中子捕獲... | ||||
| 110 | 以斑馬魚模... 以斑馬魚模式分析阿黴素心毒性之心電圖指標 (Analysis of ECG indices of doxorubicin-induced cardiotoxicity in adult zebrafish model) | NTHU NDLTD | 碩 | 0.95 |
阿黴素(doxorubicin)、心毒性(cardiotoxicity)、心電圖(electrocardiogram)、斑馬魚(zebrafish) 阿黴素(d... | ||||
| 109 | 探討轉錄因... 探討轉錄因子NF-E2相關因子2於頭頸部鱗狀細胞癌癌化過程中所扮演的角色 (Study on the role of NRF2 in malignant progression of head and neck squamous cell carcinoma) | NTHU NDLTD | 博 | 6.05 |
NF-E2 相關因子2(NRF2)、頭頸部鱗狀細胞癌(HNSCC)、代謝途徑重新編程(metabolic reprogramming)、葡萄糖-6-磷酸脫氫酶(G6PD)、轉酮醇酶(TKT)、磷酸戊糖途徑(pentose phosphate pathway)、棉酚(gossypol) NF-E2... | ||||
| 109 | 雙亞硝基鐵... 雙亞硝基鐵化合物於斑馬魚胚胎的生物相容性評估和其在斑馬魚心臟修復與再生過程中的效果 (Characterization of nitric oxide donor-dinitrosyl-iron complex by zebrafish embryotoxicity test and its effect on cardiac repair and regeneration) | NTHU NDLTD | 碩 | 0.99 |
雙亞硝基鐵化合物(Dinitrosyl Iron Complex)、斑馬魚心臟再生(Zebrafish heart regeneration)、一氧化氮(Nitric oxide)、斑馬魚胚胎毒性測試(Zebrafish embryotoxicity test) 雙亞硝基鐵... | ||||
| 109 | 探討FOX... 探討FOXO3a在EGFR抑制下介導不同p53突變型卵巢癌中細胞凋亡的作用 (Investigating the role of FOXO3a in mediating apoptosis in ovarian carcinoma with different p53 mutation states under EGFR targeted inhibition) | NTHU NDLTD | 碩 | 1.98 |
卵巢癌(Ovarian carcinoma)、表皮生長因子受體 (EGFR)(Epidermal growth factor receptor (EGFR))、艾瑞莎(Gefitinib (Iressa))、p53突變(p53 mutation)、Forkhead 轉錄因子O亞家族成員3a (FOXO3a)(Forkhead Transcription Factor O Subfamily Member 3a (FOXO3a))、細胞定位(Cellular localization)、易位(Translocation)、細胞凋亡(Apoptosis) 卵巢癌(O... | ||||
| 109 | Synde... Syndecan-4 在早期斑馬魚心臟再生過程中通過 NFAT 信號通路調節細胞外基質和電傳導的重塑 (Syndecan-4 regulates remodeling of extracellular matrix and electrical conduction via NFAT signaling pathway during the early stage of zebrafish heart regeneration) | NTHU NDLTD | 碩 | 1.96 |
Syndecan-4(Syndecan-4)、斑馬魚心臟再生(zebrafish heart regeneration)、細胞外基質重塑(ECM remodeling)、電傳導重塑(Electrical remodeling)、Calcineurin-NFAT 信號通路(Calcineurin-NFAT signaling pathway) Synde... | ||||
| 109 | 探討斑馬魚... 探討斑馬魚心臟再生過程中L型鈣離子通道對於心電圖異常與電生理重整的影響 (The Role of L-type Calcium Channel in ECG Abnormalities and Electrical Remodeling during Zebrafish Heart Regeneration) | NTHU NDLTD | 碩 | 2.50 |
L型鈣離子通道(L-type Calcium Channel)、心電圖(electrocardiography (ECG))、電生理重整(electrical remodeling)、斑馬魚(zebrafish)、心臟再生(heart regeneration) L型鈣離子... | ||||
| 109 | 透過基因共... 透過基因共表現網絡尋找心臟功能相關之基因-FAM155B的發現與實驗驗證 (Discovery and experimental validation of heart functions of FAM155B, a gene member of the heart module in human mRNA coexpression network) | NTHU NDLTD | 碩 | 2.34 |
系統生物學(Systems biology)、轉錄組(Transcriptome)、表現型(Phenome)、表徵(Functional prediction)、功能性預測(Functional genomics)、功能基因組學(Gene coexpression networks (GCNs))、基因共表現網絡(CRISPR-Cas9 techniqueCRISPR-Cas9)、基因編輯技術(Zebrafish)、斑馬魚(cardiovascular diseases (CVDs))、心血管疾病(Heart function)、心臟功能(undefined) 系統生物學... | ||||
| 108 | 探討Gef... 探討Gefitinib和Serdemetan（JNJ-26854165）之藥物組合對卵巢癌DNA損傷反應的協同作用機制 (Mechanism of Drug Combination: Synergetic effect of Gefitinib and Serdemetan (JNJ-26854165) on DNA Damage Responses in Ovarian Cancer) | NTHU NDLTD | 碩 | 1.99 |
卵巢癌(Ovarian cancer)、毛細血管擴張共濟失調突變(Ataxia telangiectasia mutated (ATM))、表皮生長因子受體(p53)、組合療法(epidermal growth factor receptor (EGFR)) 卵巢癌(O... | ||||
| 108 | 組蛋白去乙... 組蛋白去乙醯酶抑制劑做為增敏劑增強硼中子捕獲治療對黑色素瘤之療效 (Histone Deacetylase Inhibitor sensitizes melanoma cells for Boronophenylalanine-Mediated Neutron Capture Therapy) | NTHU NDLTD | 碩 | 1.98 |
硼中子捕獲治療(BNCT)、黑色素瘤(Melanoma)、組蛋白去乙醯酶抑制劑(HDACi)、DNA 雙股斷裂(DNA DSBs)、DNA 損傷反應(DNA damage response) 硼中子捕獲... | ||||
| 108 | 探討組蛋白... 探討組蛋白去乙醯酶抑制劑與化療藥物Etoposide同時或順序性複合療法對惡性黑色素瘤細胞的協同抑制作用 (Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor with Chemotherapeutic Agent Etoposide on Malignant Melanoma Cells) | NTHU NDLTD | 碩 | 0.96 |
協同抑制作用(Synergistic effect)、黑色素癌(Melanoma)、組蛋白去乙醯酶抑制劑(Histone deacetylase inhibitor (HDACi))、複合治療(Combination therapy)、藥物施用順序(Drug sequential order) 協同抑制作... | ||||
| 108 | 蟲草素透過... 蟲草素透過調節FAK和p53抑制內皮細胞增生、轉移、血管新生及腫瘤生長 (Cordycepin suppresses endothelial cell proliferation, migration, angiogenesis and tumor growth by regulating focal adhesion kinase and p53) | NTHU NDLTD | 博 | 7.48 |
血管新生(angiogenesis)、蟲草素(cordycepin)、內皮細胞(endothelial cells)、黏著斑激酶(FAK)、p53腫瘤抑制蛋白(p53) 血管新生(... | ||||
| 107 | synde... syndecan-4基因編輯斑馬魚品系的建立與利用其探討心臟修復機制的初步分析 (Generation of a syndecan-4 gene-edited zebrafish and its preliminary characterization during heart healing) | NTHU NDLTD | 碩 | 1.98 |
斑馬魚(Zebrafish)、冷凍創傷(Cryoinjury)、心臟再生(Heart regeneration)、Syndecan-4(Syndecan-4)、CRISPR(CRISPR) 斑馬魚(Z... | ||||
| 107 | 探討肝癌細... 探討肝癌細胞株接受以硼酸為含硼藥物之硼中子捕獲治療後的DNA損害反應 (In Vitro Analysis of DNA Damage Responses after Boric acid-mediated Boron Neutron Capture Therapy in a Hepatocellular Carcinoma Cell Line) | NTHU NDLTD | 碩 | 1.95 |
硼中子捕獲治療(BNCT)、肝癌(Hepatocellular carcinoma)、DNA 損傷(DNA damage)、DNA 修復(DNA repair) 硼中子捕獲... | ||||
| 107 | p53的R... p53的R248Q突變改變了高分化漿液性卵巢癌中的分子運輸和標靶藥物反應 (R248Q mutation of p53 alters molecular trafficking and targeted drug responses in high-grade serous ovarian carcinoma) | NTHU NDLTD | 碩 | 0.85 |
p53(p53)、表皮生長因子受體（EGFR）(epidermal growth factor receptor (EGFR))、Akt(Akt)、MDM2(mouse double minute 2 homolog (MDM2))、複合式療法(combination therapy) p53(p... | ||||
| 107 | 探討標靶治... 探討標靶治療在高分化漿液性卵巢癌中的協同致死作用 (Determining Cooperative Lethal Effect of Targeted therapy in High-Grade Serous Ovarian Carcinoma) | NTHU NDLTD | 碩 | 2.48 |
卵巢癌(Ovarian cancer)、協同致死作用(Cooperative lethal effect)、TP53(TP53)、標靶治療(Targeted therapy) 卵巢癌(O... | ||||
| 107 | 模式生物斑... 模式生物斑馬魚的心電圖檢測平台應用於藥物篩檢及電生理研究 (Zebrafish in vivo electrocardiogram platform for drug assay and electrophysiology research) | NTHU NDLTD | 博 | 6.45 |
斑馬魚(zebrafish)、心電圖(electrocardiography)、心律不整(arrhythmia)、藥物篩檢(drug assay) 斑馬魚(z... | ||||
| 106 | Trans... Transglutaminase-2 是斑馬魚心臟再生期間 細胞外基質重塑的調節因子 (Transglutaminase-2 is a regulator of extracellular matrix remodeling during zebrafish heart regeneration) | NTHU NDLTD | 碩 | 1.85 |
心肌梗塞(Myocardial infarction)、心臟纖維化(Cardiac fibrosis)、心臟再生(Heart regeneration)、斑馬魚(Zebrafish)、細胞外基質(Extracellular matrix)、轉麩醯胺酸酶-2(Transglutaminase-2) 心肌梗塞(... | ||||
| 106 | 研究兩個與... 研究兩個與 Notch 相關基因, mind bomb 與 nicastrin, 在 斑馬魚早期發育上所扮演的角色 (Study the roles of two Notch related genes, mind bomb and nicastrin, in zebrafish early development) | NTHU NDLTD | 博 | 6.42 |
發育(development)、肌節(somite)、黑色素細胞(melanocyte)、粒線體(mitochondria) 發育(de... | ||||
| 105 | 斑馬魚心臟... 斑馬魚心臟修復早期過程中Syndecan-4的功能 (The characterization of syndecan-4 in early stage of adult zebrafish heart regeneration) | NTHU NDLTD | 碩 | 1.99 |
斑馬魚(Zebrafish)、冷凍創傷(Cryoinjury)、心臟再生(Heart regeneration)、Syndecan-4(Syndecan-4)、心電圖(Electrocardiogram) 斑馬魚(Z... | ||||
| 105 | 肝癌細胞吸... 肝癌細胞吸收硼酸的機制及腫瘤微環境特性對於硼酸吸收的影響探討 (Mechanism analysis and effect of tumor microenvironment properties on the uptake of boric acid in human hepatoma HepG2 cells) | NTHU NDLTD | 碩 | 1.92 |
肝癌(Hepatocellular carcinoma)、硼中子捕獲治療(Boron neutron capture therapy)、硼酸運輸(Boric acid transportation)、細胞膜通透性(Cell membrane permeability)、酸性微環境(Acidic microenvironment) 肝癌(He... | ||||
| 105 | Synde... Syndecan-4 在斑馬魚心臟創傷後心臟修復與傷疤形成所扮演的角色 (Syndecan-4 is critical for scar formation in adult zebrafish heart injury and repair) | NTHU NDLTD | 碩 | 2.35 |
斑馬魚(zebrafish)、心臟再生(heart regeneration)、傷疤形成(scar formation) 斑馬魚(z... | ||||
| 105 | 新穎上皮細... 新穎上皮細胞生長因子接受體抑制劑藉由抑制腫瘤生長及轉移展現對人類頭頸鱗狀細胞癌的治療效益 (A Novel EGFR Inhibitor Exhibits the Therapeutic Efficacy via the Inhibition of Tumor Growth and Metastasis in Human Head and Neck Squamous Cell Carcinoma) | NTHU NDLTD | 碩 | 2.05 |
頭頸部鱗狀細胞癌(head and neck squamous cell carcinoma)、惡性轉移(metastasis)、間質-上皮細胞轉換(mesenchymal-epithelial transition)、G1期停滯(G1-phase arrest)、表皮生長因子接受器酪胺酸激酶抑制劑(EGFR tyrosine kinase inhibitor)、表皮生長因子接受器(epidermal growth factor receptor) 頭頸部鱗狀... | ||||
| 104 | 以硼酸為中... 以硼酸為中子捕獲治療藥物於腫瘤治療之作用機制探討 (Mechanism of Action Analysis for Boric Acid-Mediated Neutron Capture Therapy of Cancer) | NTHU NDLTD | 碩 | 無口試日期 |
硼中子捕獲治療(Boron Neutron Capture Therapy)、硼酸(BNCT) 硼中子捕獲... | ||||
| 104 | 探討混合型... 探討混合型標靶藥物於高分化漿液性卵巢癌的協同致死率 (Investigating Cooperative Lethal Effect of EGFR and MDM2 Inhibitors on High-Grade Serous Ovarian Carcinoma) | NTHU NDLTD | 碩(外籍生) | 無口試日期 |
卵巢癌(Ovarian cancer)、精準醫學(Precision medicine)、標靶藥物治療(Target therapy)、藥物協同相互作用(Cooperative effect) 卵巢癌(O... | ||||
| 104 | 保康絲(柔... 保康絲(柔沛)和雌激素在成年斑馬魚小腦創傷後的影響 (The effect of finasteride and estradiol on adult zebrafish with traumatic cerebellum injury) | NTHU NDLTD | 碩 | 無口試日期 |
腦創傷(traumatic brain injury)、神經再生(neurogenesis)、雌激素(estrogen)、斑馬魚(zebrafish)、柔沛(finasteride) 腦創傷(t... | ||||
| 103 | Molec... Molecular analysis on traumatic brain injury induced epileptic seizure in zebrafish (利用分子層次的分析探討斑馬魚腦創傷誘發癲癇發作的機制) | NTHU NDLTD | 碩 | 無口試日期 |
腦創傷(TBI)、癲癇(Epileptic seizures)、斑馬魚(Zebrafish) 腦創傷(T... | ||||
| 103 | 新穎白芷素... 新穎白芷素衍生物藉由重置癌細胞代謝有效抑制人類鱗狀癌細胞之研究 (A Novel Angelicin Derivative Inhibits Proliferation of Human Squamous Cell Carcinoma Cells by Reprogramming Cancer Metabolism) | NTHU NDLTD | 碩 | 無口試日期 |
白芷素(angelicin)、抗癌藥物(anti-cancer drug)、癌症治療(cancer therapy)、鱗狀細胞癌(squamous cell carcinoma)、細胞停滯(cytostasis)、DNA損傷(DNA damage)、S期停滯(S-phase arrest)、癌症代謝(cancer metabolism)、瓦氏效應(Warburg effect) 白芷素(a... | ||||
| 103 | Epith... Epithelial-to-mesenchymal transition in zebrafish epicardium is associated with inflammatory response during heart regeneration (發炎反應對於斑馬魚心外膜細胞間質化的影響及機制之探討) | NTHU NDLTD | 碩 | 無口試日期 |
斑馬魚(Zebrafish)、心外膜(Epicardium)、間質化(Epithelial-to-mesenchymal transition) 斑馬魚(Z... | ||||
| 102 | 子宮頸神經... 子宮頸神經內分泌腫瘤之細胞株的建立、特徵鑑定與應用 (Establishment and Characterization of a New Cell Line (HM-1) from Neuroendocrine Tumor of the Uterine Cervix) | NTHU NDLTD | 碩 | 無口試日期 |
子宮頸神經內分泌腫瘤(Neuroendocrine tumor of uterine cervix) 子宮頸神經... | ||||
| 101 | 建立用於探... 建立用於探討心肌梗塞與其治療發展的整合性斑馬魚研究平台 (An integrated zebrafish-based assay platform for the study of myocardial infarction and therapeutics development) | NTHU NDLTD | 碩 | 無口試日期 |
斑馬魚、心肌梗塞、藥物發展平台 斑馬魚、心... | ||||
| 101 | 探討神經起... 探討神經起源的Thsd7a在血管新生過程中調控內皮尖端與莖稈細胞功能的分子機制 (The molecular mechanism of neuronal THSD7A on endothelial tip and stalk cell selection during angiogenesis) | NTHU NDLTD | 碩 | 無口試日期 |
斑馬魚、血管新生、神經血管交互作用 斑馬魚、血... |